Serenin Vet® (45ct)

Serenin Vet^® combines different ingredients that work together to promote normal behavioral patterns and a healthy nervous system, particularly in times of stress. These ingredients work together to achieve this calming effect and include:

• St. John’s Wort extract, to promote normal behavioral patterns and functioning of the brain and nervous system.
• Eleuthero powder, to support behavioral responses to stress.
• Passion flower extract, which promotes relaxation.
• DL-phenylalanine, an essential amino acid that promotes normal behavior and attention and balances temperament.
• 5-HTP (Griffonia simplicifolia seed), from an African evergreen climbing shrub, promotes calming behaviors by supporting a normal nervous system response to stress.

Special Note: If your animal is pregnant or actively breeding, or is receiving any medications for behavioral management, please contact Animal Necessity Veterinary Consultants or call us at 1-800-721-1310, or contact your veterinarian before using this supplement.

Special Note: St. John’s wort in Serenin Vet^® is metabolized by the Cytochrome P450 liver pathway similar to CBD. Therefore, if taking both supplements, contact ANVision Necessity^®.

Serenin Vet^® combines different ingredients that work together to promote normal behavioral patterns and a healthy nervous system, particularly in times of stress. These ingredients work together to achieve this calming effect and include:

• St. John’s Wort extract, with active constituents hyperforin and hypericin, promotes healthy mentation and behavioral patterns by modulating serotonin, dopamine, and norepinephrine; reducing serotonin reuptake in the brain; and inhibiting GABA ligand binding.¹
• Eleuthero powder, an adaptogen, aids in the body’s ability to cope with environmental stress and anxiety by modulating the nitric oxide and cortisol production via the hypothalamic-pituitary axis.²
• Passion flower extract, containing flavonoids and alkaloids, promote relaxation by inhibiting GABA uptake by nerve cell synapses.³
• DL-phenylalanine, an essential amino acid promoting normal mood and behavior by maintaining healthy amounts of norepinephrine, as it is a precursor for the neurotransmitter’s production, and by its conversion to the metabolite neuromodulator 2-phenylethylamine to encourage brain neuron receptor sensitivity.⁴
• 5-HTP (Griffonia simplicifolia seed), a metabolite produced from essential amino acid L-tryptophan and a direct precursor for serotonin production in the CNS that promotes serotonin production and thereby healthy behavioral responses in times of stress.⁵

Special Considerations: Not recommended for use in pregnant or actively breeding without veterinary consultation. Also not recommended for use if patient is receiving any other behavior modification medications, like MAOI’s. Recommend to give with food to reduce change of gastrointestinal upset. If any questions, please contact Animal Necessity Veterinary Consultants or call us at 1-800-721-1310, or contact your veterinarian before using this supplement.

References

¹ Butterweck V, Wall A, Lieflander-Wulf U, Winterhoff H, and Nahrstedt A. Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry. 1997; 30(Suppl 2): 117-124.

² Wilson L. Review of adaptogenic mechanisms: Eleuthrococcus senticosus, Panax ginseng, Rhodiola rosea, Schisandra chinensis, and Withania somnifera. Australian Journal of Medical Herbalism. 2007; 19(3): 126-131.

³ Appel K, Rose T, Fiebich B, Kammler T, Hoffman C, and Weiss G. Modulation of the γ-aminobutyric acid (GABA) system by Passifora incarnata L. Phytother Res. 2011; 25(6): 838-843.

⁴ Kravitz HM, Sabelli HC, and Fawcett J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath Assoc. 1984; 84(1 Suppl): 119-123.

⁵ Birdsall TC. 5-Hydroxytryptophan: A clinically effective serotonin precursor. Altern Med Rev. 1998; 3: 271-280.