Eye-SEA™ (500 ct)
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Eye-SEA™ (500 ct) thumbnail
Eye-SEA™ (500 ct) thumbnail

Eye-SEA™ (500 ct)

Eye-SEA is specifically formulated by board certified veterinary ophthalmologists for long term ocular health in large animals.
Click thumbnails to learn more about each ingredient:
Lutein is a rich source of carotenoid antioxidants necessary for protection against free radical damage in the retina and lens.
Omega-3 Fatty Acids
Omega-3 Fatty Acids
Omeg-3 fatty acids contain essential fatty acids EPA and DHA that cannot be made by the body and support retinal health.
Omega-3 Fatty Acids
Grape Seed Extract
Grape Seed Extract
Grape Seed Extract is rich in antioxidants and proanthocyanidins which support the normal inflammatory response and are powerful free radical scavengers.
Grape Seed Extract
Alpha Lipoic Acid
Alpha Lipoic Acid
Alpha Lipoic Acid, or ALA, is an occurring antioxidant that's made in the body. Alpha Lipoic Acid is a universal antioxidant that is important for normal liver function and vision.
Alpha Lipoic Acid
Vitamin E
Vitamin E
Vitamin E is found naturally in some foods, added to others, and available as a dietary supplement. Vitamin E is the collective name for a group of fat-soluble compounds that provide antioxidant support.
Vitamin E
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500 Capsules per Bottle     //     Product Code: ANSEA500     //     Price For US Customers Only.
  • General Info
  • For Veterinarians
  • Directions for Use
  • Ingredients

Eye-SEA is a unique blend of select antioxidants that provides support to all structures of the eye. This supplement is formulated such that each ingredient, which is well-described below, works in concert with the others to optimize antioxidant activity and support overall ocular health.

Eye-SEA has been formulated by veterinary ophthalmologists based on clinical research.

Proprietary Blend: FloraGLO® Lutein 5%, Imuno-2865™, Omega-3 fatty acids, Lycopene (tomato extract), Silymarin 80% extract:

  • Lutein is an important carotenoid that helps maintain ocular health through its antioxidant properties.1,2
  • Imuno-2865™ is a proprietary blend of natural ingredients that help to support proper immune function.
  • Omega-3 fatty acids provide EPA and DHA, which are antioxidants that support a healthy immune. DHA has been specifically proven to protect the retina and lens from oxidants.3
  • Lycopene, extracted from tomatoes, is the most potent carotenoid. In animals, lycopene has demonstrated the ability to promote health and clarity of the ocular lens.4
  • Silymarin extract is derived from milk thistle and is a potent antioxidant that upregulates other antioxidant enzymes, like superoxide dismutase and glutathione peroxidase, to support overall cellular health.5

Proanthocyanidins (flavonoids):

  • Grape Seed Extract 95%: Grape seed extract is a strong antioxidant that scavenges free radicals and has been proven to maintain the health of the retina, including the photoreceptors.6
  • Bilberry Extract (Vaccinium myrtillus standardized for 25% anthocyanidins): Bilberry promotes the transport of glutathione, the predominant antioxidant found in the lens, into the eye.7
  • Pinebark Extract: Pine bark enhances retinal health with its ability to cross the blood brain barrier to strengthen vessel walls and promote circulation and neovascularization.

Lutein (Beadlet form) and Zeaxanthin Elementals

The beadlet form of lutein is derived from the marigold plant and is a particularly potent antioxidant.8 Both lutein and zeaxanthin9 concentrate in the cones of the retina to attenuate harmful wavelengths of blue light, found in the visible light spectrum and in UV rays. Over time, retinal exposure to blue light leads to degeneration, so by protecting the retina from these harmful wavelengths, retinal health is preserved as the pet ages.

Alpha Lipoic Acid

Alpha lipoic acid (ALA) is found in small amounts in all mammalian tissues.10 ALA is an aldose reductase inhibitor, which discourages circulating sorbitol, and subsequent glucose, from depositing in the lens. ALA is also a strong antioxidant that supports the availability of circulating ascorbate, vitamin E, and glutathione for tissue use.

Vitamin E (as d-alpha-tocopherol)

Vitamin E is a fat-soluble vitamin that is a potent antioxidant. Fatty acid oxidation occurs during the processing of fish fed to marine animals, which degrades naturally occurring vitamin E. Supplementation therefore provides animals with antioxidant support to maintain a healthy immune system while under human care.

Folic Acid (as folate)

Folic acid supports the body’s natural antioxidant defenses as a cofactor for S-adenosyl-L-methionine (SAMe) and homocysteine recycling.

Coenzyme Q10 (ubiquinone)

Coenzyme Q10 is a lipid soluble antioxidant that helps to maintain normal fat metabolism. It has been proven to decrease in the human eye with age, so supplementation helps protect the retina from age-related change.


1 Williams D, Fitchie A, Colitz C. An oral antioxidant formulation delaying and potentially reversing canine diabetic cataract: A placebo-controlled double-masked pilot study. International Journal of Diabetes and Clinical Research. 2015, 2:1.

2 Vinson JA. Review: Oxidative stress in cataracts. Pathophysiology. 2006. 13: 151-162.

3 Chucair AJ, Rotstein NP, SanGiovanni JP, et al. Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid. Investigavitve Ophthalmology and Visual Science. 2007. 28: 5168-77.

4 Gupta SK, Trivedi D, Srivastava S, et al. Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study. Nutrition. 2003. 18: 794-799.

5 Grizzle J, Hadley TL, Rotstein DS, et al. Effects of dietary milk thistle on blood parameters, liver pathology, and hepatobiliary scintigraphy in white carneaux pigeons (Columba livia) challenged with B1 aflatoxin. Journal of Avian Medicine and Surgery. 2009. 23 (3): 114-124.

6 Colitz CMH. Saville WJA, Renner MS, McBain JF, Rediarson TH, Schmitt TL, Nolan EC, Dugan SJ, Knightly F, Rodriguez MM, Mejia-Fava JC, Osborn SD, Clough PL, Collins SP, Osborn BA, Terrell K. Risk factors associated with cataracts and lens luxations in captive pinnipeds in the United States and the Bahamas. Aquatic Animals. 2010. 237 (4): 429-436.

7 Durukan AH, Everklioglu C, Hurmeric V, et al. Ingestion of IH636 grape seed proanthocyanidin extract to prevent selenite-induced oxidative stress in experimental cataract. Journal of Cataract and Refractive Surgery. 2006. 32: 1041-1050.

8 Koutsos EA, Schmitt T, Colitz CM, Mazzaro L. Absorption and ocular deposition of dietary lutein in marine mammals. Zoo Biology. 2013. 32 (3): 315-323.

9 Krinsky NI. Possible biological mechanisms for a protective role of xanthophylls. Journal of Nutrition. 2002. 132: 540S-542S.

10 Jocelyn PC. Thiols and disulfides in animal tissues. Biochemistry of the SH groups. London: Academic Press. 1972.

11 Biewenga GP, Haenen GR, A Bast. The pharmacology of the antioxidant lipoic acid. General Pharmacology. 1997; 29(3): 315-31.

Cautions: Safe use in pregnant animals or animals intended for breeding has not been proven.
Weight (lbs.) Daily Use
Suggested Maintenance Support
50 or less 1/2 Capsule
51 - 100 1 Capsule
101 - 200 1 Capsule A.M. and 1 Capsule P.M.
201 - 300 2 Capsules A.M. and 1 Capsule P.M.
301 - 500 2 Capsules A.M. and 2 Capsules P.M.
501 - 850 3 Capsules A.M. and 3 Capsules P.M.
851 - 1100 4 Capsule A.M. and 4 Capsule P.M.
1101 - 1400 5 Capsule A.M. and 5 Capsule P.M.
1401+ Call Us for Dosage Guidelines
Suggested Higher Intake for Ocular Support
50 or less 1 Capsule
51 - 100 1 Capsule A.M. and 1 Capsule P.M.
101 - 200 2 Capsules A.M. and 1 Capsule P.M.
201 - 300 2 Capsules A.M. and 2 Capsules P.M.
301 - 500 3 Capsules A.M. and 2 Capsules P.M.
501 - 850 4 Capsules A.M. and 3 Capsules P.M.
851 - 1100 5 Capsules A.M. and 4 Capsules P.M.
1101 - 1400 6 Capsules A.M. and 5 Capsules P.M.
1401+ Call Us for Dosage Guidelines

Note: When combining Opti-Marine™ and Eye-SEA™, animals need one less capsule daily of Opti-Marine™.

Serving Size: 1 Capsule
Capsules Per Bottle: 500
Active Ingredients Amount Per Serving
Grapeseed Extract 95% 150 mg
Eye-SEA® Proprietary Blend: FloraGLO® Lutein 5%, Imuno-2865 ™, Omega-3 fatty acids, Lycopene (tomato extract), Silymarin 80% extract. 125 mg
Alpha Lipoic Acid 100 mg
Vitamin E (as d-alpha-tocopherol) 50 IU
Coenzyme Q10 (Ubiquinone) 30 mg
Pinebark Extract 30 mg
Lutein Elemental (Beadlet form) 20 mg
Bilberry Extract (Vaccinium myrtillus standardized for 25% anthocyanidins) 15 mg
Zeaxanthin Elemental 10 mg
Folic Acid (as Folate) 50 mcg
Inactive Ingredients: Gelatin, magnesium stearate and cellulose.
Extra Information:
Cautions: Safe use in pregnant animals or animals intended for breeding has not been proven.
PDS-2865® is a registered trademark of Innovation Laboratories, Inc.

FloraGLO® is a registered trademark of Kemin Industries, Inc. U.S.A.

Please visit http://www.floraglolutein.com to see the new studies that have been conducted with this specific lutein and its properties to support vision.