Eye-SEA™ (500 ct)

Eye-SEA^™ is a unique blend of select antioxidants that provides support to all structures of the eye. This supplement is formulated such that each ingredient, which is well-described below, works in concert with the others to optimize antioxidant activity and support overall ocular health.

Download the Material Safety Data Sheet for Eye-SEA^™ here!

Eye-SEA^™ has been formulated by veterinary ophthalmologists based on clinical research.

Proprietary Blend: FloraGLO® Lutein 5%, Imuno-2865™, Omega-3 fatty acids, Lycopene (tomato extract), Silymarin 80% extract:

• Lutein is an important carotenoid that helps maintain ocular health through its antioxidant properties.^1,2
• Imuno-2865™ is a proprietary blend of natural ingredients that help to support proper immune function.
• Omega-3 fatty acids provide EPA and DHA, which are antioxidants that support a healthy immune. DHA has been specifically proven to protect the retina and lens from oxidants.³
• Lycopene, extracted from tomatoes, is the most potent carotenoid. In animals, lycopene has demonstrated the ability to promote health and clarity of the ocular lens.⁴
• Silymarin extract is derived from milk thistle and is a potent antioxidant that upregulates other antioxidant enzymes, like superoxide dismutase and glutathione peroxidase, to support overall cellular health.⁵

Proanthocyanidins (flavonoids):

• Grape Seed Extract 95%: Grape seed extract is a strong antioxidant that scavenges free radicals and has been proven to maintain the health of the retina, including the photoreceptors.⁶
• Bilberry Extract (Vaccinium myrtillus standardized for 25% anthocyanidins): Bilberry promotes the transport of glutathione, the predominant antioxidant found in the lens, into the eye.⁷
• Pinebark Extract: Pine bark enhances retinal health with its ability to cross the blood brain barrier to strengthen vessel walls and promote circulation and neovascularization.

Lutein (Beadlet form) and Zeaxanthin Elementals

The beadlet form of lutein is derived from the marigold plant and is a particularly potent antioxidant.⁸ Both lutein and zeaxanthin⁹ concentrate in the cones of the retina to attenuate harmful wavelengths of blue light, found in the visible light spectrum and in UV rays. Over time, retinal exposure to blue light leads to degeneration, so by protecting the retina from these harmful wavelengths, retinal health is preserved as the pet ages.

Alpha Lipoic Acid

Alpha lipoic acid (ALA) is found in small amounts in all mammalian tissues.¹⁰ ALA is an aldose reductase inhibitor, which discourages circulating sorbitol, and subsequent glucose, from depositing in the lens. ALA is also a strong antioxidant that supports the availability of circulating ascorbate, vitamin E, and glutathione for tissue use.

Vitamin E (as d-alpha-tocopherol)

Vitamin E is a fat-soluble vitamin that is a potent antioxidant. Fatty acid oxidation occurs during the processing of fish fed to marine animals, which degrades naturally occurring vitamin E. Supplementation therefore provides animals with antioxidant support to maintain a healthy immune system while under human care.

Folic Acid (as folate)

Folic acid supports the body’s natural antioxidant defenses as a cofactor for S-adenosyl-L-methionine (SAMe) and homocysteine recycling.

Coenzyme Q10 (ubiquinone)

Coenzyme Q10 is a lipid soluble antioxidant that helps to maintain normal fat metabolism. It has been proven to decrease in the human eye with age, so supplementation helps protect the retina from age-related change.

References

¹ Williams D, Fitchie A, Colitz C. An oral antioxidant formulation delaying and potentially reversing canine diabetic cataract: A placebo-controlled double-masked pilot study. International Journal of Diabetes and Clinical Research. 2015, 2:1.

² Vinson JA. Review: Oxidative stress in cataracts. Pathophysiology. 2006. 13: 151-162.

³ Chucair AJ, Rotstein NP, SanGiovanni JP, et al. Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid. Investigavitve Ophthalmology and Visual Science. 2007. 28: 5168-77.

⁴ Gupta SK, Trivedi D, Srivastava S, et al. Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study. Nutrition. 2003. 18: 794-799.

⁵ Grizzle J, Hadley TL, Rotstein DS, et al. Effects of dietary milk thistle on blood parameters, liver pathology, and hepatobiliary scintigraphy in white carneaux pigeons (Columba livia) challenged with B1 aflatoxin. Journal of Avian Medicine and Surgery. 2009. 23 (3): 114-124.

⁶ Colitz CMH. Saville WJA, Renner MS, McBain JF, Rediarson TH, Schmitt TL, Nolan EC, Dugan SJ, Knightly F, Rodriguez MM, Mejia-Fava JC, Osborn SD, Clough PL, Collins SP, Osborn BA, Terrell K. Risk factors associated with cataracts and lens luxations in captive pinnipeds in the United States and the Bahamas. Aquatic Animals. 2010. 237 (4): 429-436.

⁷ Durukan AH, Everklioglu C, Hurmeric V, et al. Ingestion of IH636 grape seed proanthocyanidin extract to prevent selenite-induced oxidative stress in experimental cataract. Journal of Cataract and Refractive Surgery. 2006. 32: 1041-1050.

⁸ Koutsos EA, Schmitt T, Colitz CM, Mazzaro L. Absorption and ocular deposition of dietary lutein in marine mammals. Zoo Biology. 2013. 32 (3): 315-323.

⁹ Krinsky NI. Possible biological mechanisms for a protective role of xanthophylls. Journal of Nutrition. 2002. 132: 540S-542S.

¹⁰ Jocelyn PC. Thiols and disulfides in animal tissues. Biochemistry of the SH groups. London: Academic Press. 1972.

¹¹ Biewenga GP, Haenen GR, A Bast. The pharmacology of the antioxidant lipoic acid. General Pharmacology. 1997; 29(3): 315-31.

Note: When combining Opti-Marine™ and Eye-SEA™, animals need one less capsule daily of Opti-Marine™.